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Non-integration means an early failure of grafts or implants to take and is a reality that unfortunately exists, although in very small percentages.  In the case of grafts, bone regeneration may fail to take place.  In the case of implants, fibrous tissue adhesion may develop instead of bone attachment which means that the implant will not be able to support load and would need to be removed and if possible another implant could be placed.

When a graft or implant has not integrated successfully it can be for several reasons including poor health, poor oral cleansing, poor surgical insertion technique, smoking, or for reasons unknown.  When a dental implant fails to integrate for reasons unknown, the failure is sometimes erroneously referred to as rejection. The titanium material used in dental implants is considered to be so highly biocompatible that rejection because of the material seems quite unlikely.

Non-integration statistically runs at around 3% worldwide.  More experienced clinicians usually will get better percentage results than will novice clinicians.  All things considered, the placement of either regenerative bone grafts or dental implants, while not perfect, can be expected to have excellent success.